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Rybelsus contains semaglutide, a glucagon-like peptide-1 Rybelsus medication. The GLP-1 hormone is naturally produced in the gut and has a significant role in managing blood sugar levels. It works by stimulating the release of insulin from the pancreas when glucose levels are high and also reducing the amount of glucose produced by the liver. However, natural GLP-1 is quickly degraded in the body.