Why Do Astronauts Lose Muscle in Orbit Despite Exercising Every Day?

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Astronauts exercise regularly aboard the space station, yet muscle loss is still discussed as a health concern during long missions. If their workout schedule is built into the day, what makes maintaining strength in orbit so difficult?

I’m curious about how muscle loss in orbit differs from ordinary deconditioning on Earth. Does the lack of constant loading from gravity affect certain muscles more than others, or is the challenge mainly the limits of exercising in a spacecraft?

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