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Runtime Mismatch
You upgraded the .NET runtime on your server, but the application pool still points to the older version. The result? A crash on launch with a cryptic "Unable to find the specified file" error.
Checking the actual runtime
Open a command prompt and run dotnet --list-runtimes. If the version you need is missing, install it via the Microsoft Install Script or your OS package manager. Do not assume the global SDK installation covers the server runtime.
- Verify the app pool in IIS points to the correct .NET CLR version.
- Restart the application pool after any runtime change.
- Check the event viewer for binding failures before reinstalling anything.