When faced with a non-responsive mouse, it can be frustrating, but there are several steps you can take to troubleshoot and potentially resolve the issue. Here's a comprehensive guide:

• Check Physical Connections:   Ensure that your mouse is properly connected. For wired mice, check the USB or PS/2 connection, and for wireless mice, verify that the receiver is securely plugged into a functional USB port.
• Try a Different USB Port:   If you are using a wired mouse, switch to a different USB port. Sometimes, a faulty port can lead to connectivity issues.
• Replace or Recharge Batteries:   If you are using a wireless mouse, check the battery status. Replace the batteries with new ones or recharge them if applicable. Low battery levels can result in the mouse not responding.
• Examine for Physical Damage:   Inspect the mouse for any physical damage, such as frayed cables or broken connectors. If there is damage, consider repairing or replacing the mouse.
• Restart Your Computer:   A normal restart can also sometimes resolve minor abnormalities. Reboot your computer and check if the mouse starts responding again.
• Update Mouse Drivers:   Outdated or incompatible drivers may cause issues. Update your mouse drivers through the Device Manager on Windows or System Preferences on macOS. Subsequently, visit the manufacturer's webpage to download and install the up-to-date drivers.
• Attempt Another Mouse:   If possible, connect a different mouse to your computer to determine whether the issue lies with the mouse itself or the computer's settings.
• Check for Software Conflicts:   Some third-party mouse-related software or drivers may conflict with the device. Temporarily disable or uninstall any such software to check if it resolves the issue.
• Test on Another Computer:   Connect your mouse to another computer to check if it works. If the mouse functions correctly on a different system, the issue might be with your computer's settings or drivers.
• Review System Settings:    Examine your computer's mouse settings in the operating system. Ensure that the mouse is recognized and configured correctly. Adjust sensitivity, button assignments, and other settings as necessary.
• Perform a System Restore:    If the mouse issue started recently and you are using a Windows system, consider using System Restore to revert your computer to a previous state when the mouse was working correctly.

By systematically going through these steps, you can identify and address the potential causes of the non-responsive mouse. If the problem persists, seeking assistance from the mouse's manufacturer or your computer's support channels may be necessary.