The United States's major enemies are a matter of perception and opinion, but some countries that are frequently mentioned include:

• China: China is the world's second-largest economy and a major military power. The United States and China have been engaged in a trade war in recent years, and there are concerns about China's growing influence in the world.

• Russia: Russia is a nuclear-armed country with a long history of conflict with the United States. The two countries have been at odds over issues such as Ukraine, Syria, and nuclear proliferation.
• Iran: Iran is a Shiite Muslim country that has been accused of supporting terrorism. The United States and Iran have been at odds over the Iranian nuclear program, and there have been fears that Iran could develop nuclear weapons.
• North Korea: North Korea is a totalitarian state with a nuclear weapons program. The United States and North Korea have been engaged in a standoff over the North Korean nuclear program for decades.
• Venezuela: Venezuela is a country in political and economic crisis. The United States has imposed sanctions on Venezuela, and there are concerns that the country could become a failed state.

These are just some of the countries that are frequently mentioned as the United States's major enemies. The list of enemies may change over time, depending on the political and economic climate.

It is important to note that the United States does not officially have any enemies. The US government prefers to use the term "adversary" to describe countries that it has significant disagreements with. However, the term "enemy" is often used in the media and by the public to describe countries that are seen as a threat to the United States.